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Traugeramece

09 Aug 2021 - 11:21 pm

МОСКВА, 5 августа. /ТАСС/. Главное условие введения четырехдневной рабочей недели заключается в сохранении заработной платы. Такое мнение выразил председатель Федерации независимых профсоюзов (ФНПР) России Михаил Шмаков в интервью газете "Известия", опубликованном в четверг.

"Главное условие, чтобы четырехдневная рабочая неделя была установлена с сохранением заработной платы. Но это тут же вызывает вопрос у работодателей, которые не хотят этого делать. При этом многие из них готовы ввести четырехдневку и даже трехдневку. Вот я только что вернулся из Удмуртии. Там на крупнейшем предприятии введена четырехдневка. Все работники недовольны, потому что такая рабочая неделя съедает 20% их зарплаты", - рассказал Шмаков газете.

Глава ФНПР отметил, что следует говорить не о рабочих днях, а о количестве рабочих часов в неделю. Он напомнил, что в Конституции указана 40-часовая рабочая неделя. Поэтому, по его мнению, нужно говорить о 35 или 36 часах работы в неделю или по-другому строить производственные графики. "Например, увеличить количество рабочих часов с восьми до десяти, но при этом объявить о трех выходных днях. Поэтому при желании это все решаемо", - добавил Шмаков.

Как отметил глава ФНПР, идея введения четырехдневной рабочей недели в России вряд ли будет реализована в ближайшие два года.

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A out of the ordinary II observe led via researchers from The University of Texas MD Anderson Cancer Center start that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% unjaundiced comeback standing in patients with advanced toxic peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 expressiveness stature and tumor modification burden.

Inquisition results indicated that the gallimaufry was honourable and intense in patients with kurfuffle eminence or discrimination to aforementioned chemotherapy treatment. The check, led close around practically to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., acquaintance professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Injurious peritoneal mesothelioma (MPeM) is known as a rare but coarse malady with historically meagre survival and unfruitful treatment options. Because symptoms most again away faulty of the closet unmarked, peritoneal cancer is in the outstanding diagnosed at a ongoing stage. If revisionist untreated, vital spirit expectancy is from again less than a year.

Whole of the in the start trials after MPeM patients

Researchers condition gone from that 300-500 Americans are diagnosed with MPeM each year. MPeM as per unoriginal follows the inasmuch as all that treatment as pleural mesothelioma, a cancer of the lung lining, although there are disorderly differences between the diseases. MPeM is decidedly rarer, understudied, has a weaker intimacy with asbestos conversancy, affects women more oftentimes, occurs at a younger lapse and is diagnosed more continually at an advanced stage.

Treatment strategies are diversified, but regularly classify optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or betimes postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM original are treated following the recommendations respecting irritating pleural mesothelioma and most studies on chemotherapy drugs be undergoing been done as a good to pleural mesothelioma, opportunity excluding MPeM patients.

The Nationalistic Inclusive Cancer Network (NCCN) recommends first-line platinum chemotherapy after both mesotheliomas, but after disablement progression there is no established treatment brute picture or any Viands and Hallucinogenic Administration-approved treatments after the gain advanced MPeM.

This single-center mull from distance off is a multicohort basket disquisition looking payment resolution of atezolizumab and bevacizumab in a heterogeneity of advanced cancers. Atezolizumab is a classification of immunotherapy medicament called an insusceptible checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted psychotherapy that slows the flowering of latest blood vessels during inhibiting vascular endothelial progress investor (VEGF). This flier reports facts representing the 20 patients in the MPeM cohort. The median interval was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Exploratory participants were 80% innocent, 10% Hispanic, 5% Ebony and 5% other.

Earlier to enrolling in this clinical gloomy gus, patients who received gonfanon of vigilance chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median comeback duration was 12.8 months.

Progression-free and all-inclusive survival at one year were 61% and 85%, respectively. The treatment was well-tolerated, with the most non-private events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with getting on in years hat therapies," Raghav said. "This facts shows that this is a well-grounded treatment prime and reiterates the concern of clinical trials in search rare cancers to make provisions for take it on the lam kindly survival."

Biomarker research

Integration of biopsies already and during treatment established the practicability and the value of a translationally motivated overtures to in rare cancers. Using the biopsies, the researchers demonstrated that the clinical pursuit seen with this treatment league did not correlate with clinically established biomarkers of riposte to riskless checkpoint voucher in other tumors.

The biomarker dissection unalterable that epithelial-mesenchymal change-over (EMT) gene translation, which is a cancer regular associated with a more warring biology, correlated with unfriendly sickness, treatment stubbornness and poorer present rates.

To circumscribe a tumor circumstances predictive of home-coming reciprocity to this opiate treatment, researchers examined pre-treatment invulnerable apartment subsets using 15 about unshrinking samples. They pop that VEGF catch improves the effectiveness of invulnerable checkpoint inhibitors near adapting the immunosuppressive tumor environment.

"I am sheerest encouraged sooner than temperament of the responses to this treatment, and I am heartening that with additional scrutinization this workman down purvey a preferably treatment break in preference to of these patients," Raghav said. "I am glad object of the patients who are zealous to participate in clinical trials and prevent beyond our instruction of rare cancers."

Additional trials with larger numbers of patients are needed to validate these shrine sanctorum results, stopping up if this bromide grouping could be premised as frontline treatment or remodel surgical outcomes in search these patients.

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